Erectile dysfunction affects 30-50% of men over the age of 40. Current medical interventions for the management of erectile dysfunction include drugs, intrapenile therapies, and penile prosthetic implants. Korean red ginseng (Panax ginseng) is the steamed and dried roots of plants that are harvested six years after planting. One of the popular uses of red ginseng is the enhancement of sexual function. Few clinical trials have evaluated the effect of red ginseng on erectile dysfunction, and recent reviews of erectile dysfunction therapies did not include studies published in languages other than English. The purpose of this systematic review was to critically evaluate the evidence from all randomized controlled trials (RCTs) of red ginseng in men with erectile dysfunction.
Researchers at the Korea Institute of Oriental Medicine searched electronic databases from their inception until January 2008. The databases included MEDLINE, AMED (Allied and Complementary Medicine Database), British Nursing Index, CINAHL (Cumulative Index to Nursing and Allied Health Literature), EMBASE (Excerpta Medica Database), PsycInfo, The Cochrane Library, six Korean medical databases, four Chinese medical databases, and three Japanese medical databases. The researchers also manually searched relevant journals and checked the references of all articles identified in the search. The analysis included all articles that reported on a RCT in which human subjects with any type of erectile dysfunction were treated with any type of red ginseng, regardless of language of publication. Three independent reviewers read, extracted, and rated each article.
The researchers identified 28 potentially relevant trials, and 7 of these trials met the criteria for inclusion in the analysis. A total of 363 men, ranging in age from 24 to 70 years, were studied in these 7 trials. The duration of treatment with red ginseng ranged from 4 to 12 weeks. The doses of red ginseng ranged from a daily total of 1800 mg to 3000 mg. Outcome measures included scores on the International Index of Erectile Function, the Watts sexual function questionnaire, global efficacy questions, and study-specific structured interview questionnaires related to erectile function.
Six of the trials reported an improvement in erectile function in subjects taking red ginseng compared to subjects taking placebo. A meta-analysis of data from the seven trials suggests that red ginseng is superior to placebo in improving erectile function (P < size="1">
Jang D-J, Lee MS, Shin B-C, Lee Y-C, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol. October 2008;66(4): 444-450.
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